- Placental lactogen and increased cortisol contribute to increased insulin resistance, particularly later in pregnancy.
- Pregnant women have respiratory alkalosis with decreased serum bicarbonate concentrations and reduced capacity to buffer organic acids.
- Pregnancy being an accelerated state of starvation, overnight fast can increase lipolysis and ketone body concentrations 2-4 times greater than in nonpregnant state.[1, 5]
- Predisposing factors for DKA include stress of labor, cessation of insulin therapy, use of β-sympathomimetic agents and emesis with accompanying dehydration.
- Both fetus and placenta utilize large quantities of glucose resulting in lower maternal fasting glucose levels.[2, 3, 4 ]
Editor-in-chief: Parulekar SV
Co-editor: Gupta AS, Honavar PU.
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